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DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
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Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides.

Koen Nauwelaerts1, Eveline Lescrinier, Gert Sclep

  • 1Rega Institute for Medical Research, Laboratory for Medicinal Chemistry Minderbroedersstraat 10, B-3000 Leuven, Belgium.

Nucleic Acids Research
|May 3, 2005
PubMed
Summary

Cyclohexenyl nucleic acid (CeNA) mimics natural DNA sugars, showing similar conformational flexibility. This synthetic nucleoside uniquely adopts varied conformations within different DNA duplexes, revealed by NMR spectroscopy.

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