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Simultaneous onset of pemphigus vulgaris in two Turkish siblings
Ayşe Kavak1, Ilker Aydoğan, Sevim Gönen
1Abant Izzet Baysal University, Duzce Medical School, Department of Dermatology, Duzce, Turkey.
The Journal of Dermatology
|May 3, 2005
Abstract:
The etiology of pemphigus vulgaris is still unknown. Reported familial cases are indicators of a genetic aspect of the disease. We report a brother and sister with simultaneous onset of pemphigus vulgaris. The class II antigens, HLA DRB1*04 and DQB1*03 were detected in both patients. The oral mucosa was affected in one them. Elevation of transaminase levels due to azathioprine therapy was observed in these two cases.