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Essential Components of Borreliella (Borrelia) burgdorferi In Vitro Transcription Assays
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The versatile roles of antibodies in Borrelia infections

Sean E Connolly1, Jorge L Benach

  • 1Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York 11794-5120, USA.

Nature Reviews. Microbiology
|May 3, 2005
PubMed

Antibodies are the primary weapons of the mammalian immune system that are used against the tick-borne borreliae, the causative agents of relapsing fever and Lyme disease worldwide. Some antibody responses have 'traditional' functions, whereas others are more versatile and have novel functions and modes of action. At a time when the multiple functions of antibodies are being increasingly recognized and passive immunization is being revived as therapy for infectious and other diseases, the versatile nature of the antibody response to the borreliae fits well with this antibody renaissance.

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