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Published on: June 29, 2013
Major ozonated autohemotherapy in chronic limb ischemia with ulcerations
Amato de Monte1, Hoyte van der Zee, Velio Bocci
1Erasmus Medical Center, Rotterdam, Netherlands. demonte@xnet.it
Summary
Ozone autohemotherapy (OHT) shows promise for healing intractable leg ulcers in patients with diabetes and vasculitis. This therapy led to satisfactory ulcer healing after several months of treatment.
Area of Science:
- Regenerative Medicine
- Vascular Biology
- Pain Management
Background:
- Intractable leg ulcers pose a significant challenge in patients with diabetes mellitus type II and vasculitis.
- Conventional treatments and pain management strategies, including chemical sympathectomy and epidural blockade, provided only moderate pain relief without ulcer healing.
Observation:
- Two patients with severe, painful leg ulcers unresponsive to standard care presented to a pain clinic.
- Despite multimodal pain management, ulcer progression continued, leading to intolerable pain.
Findings:
- Ozone autohemotherapy (OHT) was administered over several months.
- Satisfactory healing of the intractable leg ulcers was observed following OHT treatment in both patients.
Implications:
- OHT may represent a novel therapeutic option for refractory leg ulcers, particularly in complex cases involving diabetes and vasculitis.
- Further research into OHT mechanisms and efficacy in wound healing is warranted.
- This case series suggests OHT could improve outcomes for patients with non-healing wounds.
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