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Neutrophil CD64 expression in Behçet's disease
Kemal Ureten1, Ihsan Ertenli, M Akif Oztürk
1Department of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey.
The Journal of Rheumatology
|May 4, 2005
Summary
Neutrophil CD64 expression is elevated in active Behçet
Area of Science:
- Immunology
- Rheumatology
- Cell Biology
Background:
- Neutrophil hyperfunction is characteristic of Behçet's disease (BD).
- Fc gamma receptor 1 (CD64) is upregulated on neutrophils in response to inflammation.
- CD64 expression differs between autoimmune and infectious diseases.
Purpose of the Study:
- To investigate polymorphonuclear leukocyte (PMN) CD64 expression in patients with Behçet's disease.
- To compare CD64 expression in active BD, inactive BD, infections, and inflammatory diseases.
Main Methods:
- Flow cytometry was used to measure CD64-bearing PMN prevalence.
- Study included patients with active BD, inactive BD, infections, inflammatory disease, and healthy controls.
Main Results:
- CD64-bearing PMN prevalence was significantly higher in active BD, infectious disease, and inflammatory disease groups compared to healthy controls and inactive BD.
- Infectious disease group showed higher CD64 expression than active BD and inflammatory disease groups.
- No significant difference in CD64 expression was found between active BD and inflammatory disease groups.
Conclusions:
- Neutrophil CD64 expression increases during Behçet's disease exacerbations.
- This elevation represents a non-specific inflammatory response.
- Increased CD64 expression does not indicate PMN activation by a living microorganism.