Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biaryl isoxazolinone antibacterial agents.

Claude A Quesnelle1, Patrice Gill, Stephan Roy

  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, Discovery Chemistry, Candiac, Québec, Canada. claude.quesnelle@hms.com

Bioorganic & Medicinal Chemistry Letters
|May 5, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of Bioisosteres in the Design and Discovery of FDA-Approved Drugs and Advanced Clinical Candidates.

Journal of medicinal chemistry·2026
Same author

Targeting the H/KRAS α4-β6-α5 Allosteric Lobe with Macrocyclic Peptides.

ACS medicinal chemistry letters·2026
Same author

Development of a machine learning-based survival prediction model for ALS inclusive of the advanced-stage population.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same author

DNA-Encoded Libraries (DELs) for Discovering New Molecular Probes: Application to Live-Cell Bioimaging and Personalized Theranostics.

Bioconjugate chemistry·2026
Same author

Optimization of Covalent Warhead Trajectory for KRAS<sup>G12C</sup> Active-State Inhibition.

Journal of medicinal chemistry·2026
Same author

Optimization of α-Fluoro, β-Heteroaryl Acrylamide Warheads for KRAS<sup>G12C</sup> Active-State Inhibition.

Journal of medicinal chemistry·2026

New synthetic phenyl-isoxazolinone compounds show potent antibacterial activity against Gram-positive bacteria. This research explores novel biaryl isoxazolinone structures to combat drug-resistant infections.

Area of Science:

  • Medicinal Chemistry
  • Microbiology
  • Drug Discovery

Background:

  • Increasing bacterial resistance to antibiotics necessitates the development of novel antibacterial agents.
  • Oxazolidinone antibiotics, like Zyvox, are important for treating multi-drug resistant Gram-positive bacterial infections.
  • Previous research has identified synthetic phenyl-isoxazolinone agents with promising activity.

Purpose of the Study:

  • To synthesize and evaluate a new series of biaryl isoxazolinone compounds.
  • To investigate the structure-activity relationships of substitutions on the phenyl ring.
  • To identify novel antibacterial agents effective against Gram-positive bacteria.

Main Methods:

  • Synthesis of a series of biaryl isoxazolinone compounds.

Related Experiment Videos

  • Evaluation of antibacterial activity against Gram-positive bacterial strains.
  • Structure-activity relationship analysis through systematic chemical modifications.

    • Main Results:

    • The synthesized biaryl isoxazolinone compounds demonstrated potent antibacterial activity.
    • Specific substitutions on the phenyl ring significantly influenced the observed activity.
    • The compounds represent a promising new class of antibacterial agents.

    Conclusions:

    • Biaryl isoxazolinones are a viable new class of synthetic antibacterial agents.
    • Further development could lead to new treatments for resistant Gram-positive bacterial infections.
    • This study provides a foundation for discovering novel antibiotics to address the challenge of antimicrobial resistance.