Related Experiment Video

Updated: Aug 18, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

A curious link between epidermal growth factor receptor amplification and survival: effect of "allele dilution" on

Frederic J Kaye

    Journal of the National Cancer Institute
    |May 5, 2005
    PubMed
    Abstract

    No abstract available in PubMed .

    More Related Videos

    A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
    13:34

    A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

    Published on: April 6, 2016

    Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
    15:05

    Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

    Published on: May 20, 2020

    Related Experiment Videos

    Last Updated: Aug 18, 2026

    Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
    09:38

    Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

    Published on: August 11, 2017

    A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
    13:34

    A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

    Published on: April 6, 2016

    Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
    15:05

    Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

    Published on: May 20, 2020

    Related Concept Videos

    Mitogens and the Cell Cycle02:38

    Mitogens and the Cell Cycle

    Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
    Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

    Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

    Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

    Articles linked to this work by shared authors, journal, and citation graph.

    Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability.

    Biomaterials·2025

    Integrated proteomic analysis identifies TYMS-dependent AMPK-mTOR signaling in pancreatic neuroendocrine tumors.

    iScience·2025

    Proof-of-Concept of an Integrated Yoga and Psychological Intervention in Mitigating Distress Among Diverse Women With Gynecologic, Gastrointestinal, and Thoracic Cancers.

    Integrative cancer therapies·2024

    PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer.

    Cells·2024

    PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer.

    bioRxiv : the preprint server for biology·2024

    Nivolumab monotherapy or combination with ipilimumab with or without cobimetinib in previously treated patients with pancreatic adenocarcinoma (CheckMate 032).

    Journal for immunotherapy of cancer·2024

    Two-to-one randomization is associated with increased control-arm patient withdrawal.

    Journal of the National Cancer Institute·2026

    Trends in U.S. breast cancer mortality by estrogen receptor status.

    Journal of the National Cancer Institute·2026

    Explaining educational differences in return to work after early breast cancer: a mediation analysis.

    Journal of the National Cancer Institute·2026

    Effectiveness of an exercise intervention on cognition in breast cancer survivors: a randomized controlled trial.

    Journal of the National Cancer Institute·2026

    Exercise slows biological aging in breast cancer survivors: secondary analysis of a randomized trial.

    Journal of the National Cancer Institute·2026

    Early palliative care for African American and rural-dwelling advanced cancer family caregivers: long-term outcomes.

    Journal of the National Cancer Institute·2026

    The effect of psychiatric comorbidities on in-hospital outcomes and mortality following isolated traumatic brain injury: a retrospective cohort analysis study.

    Journal of trauma and injury·2026

    Severe Tetanus in an Older Adult Without an Identifiable Portal of Entry: A Case Report.

    Case reports in infectious diseases·2026

    Appendiceal Perforation as a Potential Indicator of Healthcare Disparities Between Thai and Non-Thai Populations: A Nationwide Study of Public Hospitals in Thailand.

    Journal of racial and ethnic health disparities·2026

    Violence-Related Emergency Medical Services Encounters in the Anatolian Side of Istanbul: A Retrospective Registry-Based Study.

    Disaster medicine and public health preparedness·2026

    Molecular confirmation of transfusion-transmitted dengue virus infection following platelet transfusion in the Chinese mainland.

    Frontiers in cellular and infection microbiology·2026

    Analysis of Epstein-Barr Virus and Tumor-Derived Circulating Plasma DNA in Children and Young Adults With Classical Hodgkin Lymphoma in East Africa.

    Pediatric blood & cancer·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us