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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Olfactory neuroblastoma: a case report and review of the literature
Shehzad Ghaffar1, Iftikhar Salahuddin
1Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, Aga Khan University Hospital, Stadium Rd., Karachi-74800, Pakistan. sgm@akunet.org
Abstract:
Malignant tumors of the nasal cavity are rare. We report the case of an elderly woman who consulted us with a 4-year history of progressive nasal obstruction, occasional epistaxis, facial pain, and watering of the eyes. A diagnosis of olfactory neuroblastoma was established by histopathology and confirmed by immunohistochemistry. On staging, the mass was classified as a Kadish stage B tumor. The mass was excised via a lateral rhinotomy approach, and the tumor was peeled away completely from the cribriform plate with endoscopes. The patient underwent postoperative radiation, and she was free of recurrence at follow-up 15 months later.