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Updated: Aug 18, 2026
Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
Published on: April 2, 2017
[Pharmacokinetics and distribution of superoxide dismutase liposomes in rats]
Yun-long Zhang1, Ying Xie, Hui-juan Wang
1Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
Aim:
To evaluate the effects of surfactants on the pharmacokinetics and distribution in rats after intravenous administration of SOD liposomes.
Methods:
The liposomes were prepared by reverse phase evaporation method. The activity of SOD was assayed by method of xanthine oxidase.
Results:
The T1/2 of SOD solution, common SOD liposome, SOD liposomes modified by DSPE-PEG2000 and Tween 80 were 0.25, 0.34, 0.66 and 0.41 h, respectively; AUC were 12.48, 24.66, 41.16 and 33.02 microg x h x mL(-1), respectively. Compared with the common liposome, the liposomes modified by DSPE-PEG and Tween 80 decreased the content of SOD in liver and spleen, but increased in brain.
Conclusion:
The three kinds of liposomes could increase T1/2 and AUC in some extent, especially in PEG-L group. Tween-L could increase the SOD content in brain, and PEG-L could decrease the SOD content in the liver and spleen compared with the common liposome.
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