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Temporal bone chondroblastoma: a review.

Liu-Guan Bian1, Qing-Fang Sun, Wei-Guo Zhao

  • 1Department of Neurosurgery, Rui-Jin Hospital, Shanghai Second Medical University, Shanghai, China. rj11118@yahoo.com

Neuropathology : Official Journal of the Japanese Society of Neuropathology
|May 7, 2005
PubMed
Summary
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Temporal bone chondroblastomas are rare tumors that can mimic other lesions. Early diagnosis using imaging and S-100 protein staining is crucial for effective surgical treatment.

Area of Science:

  • Oncology
  • Otorhinolaryngology
  • Pathology

Background:

  • Temporal bone chondroblastomas are exceptionally rare osseous neoplasms.
  • Only 45 cases have been documented in existing literature, highlighting their rarity.
  • These tumors can be misdiagnosed as more common temporal bone pathologies.

Observation:

  • A case study of a 38-year-old male with left-sided hearing loss and temporal swelling is presented.
  • Radiographic imaging revealed an osteolytic, lobulated, and expansile mass on CT scan.
  • MRI demonstrated cystic components with a fluid-fluid level and an enhanced solid mass.

Findings:

  • Histopathological analysis showed spindle-shaped tumor cells with multinucleated giant cells, oval to polygonal nuclei (some grooved), intercellular calcification, and hemorrhagic areas.

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  • Immunohistochemical staining confirmed strong positivity for S-100 protein.
  • Complete surgical excision was achieved via a left zygomatic-extended middle fossa approach, addressing eroded bone and muscle.

    • Implications:

    • Diagnostic radiology (CT/MRI) and S-100 protein immunohistochemistry are vital for accurate diagnosis.
    • Complete surgical excision is the recommended treatment, emphasizing the preservation of critical neurovascular structures.
    • Distinguishing these rare tumors from common lesions is essential for appropriate patient management.