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Updated: Aug 18, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
A modular approach to polyketide building blocks: cycloadditions of nitrile oxides and homoallylic alcohols
Nina Lohse-Fraefel1, Erick M Carreira
1Laboratorium für Organische Chemie, ETH Hönggerberg, HCI, Zürich, Switzerland.
Abstract:
A general approach to the diastereoselective synthesis of Delta(2)-isoxazolines via magnesium-mediated, hydroxyl-directed diastereoselective nitrile oxide cycloadditions of homoallylic alcohols and monoprotected homoallylic diols is disclosed. A broad spectrum of aliphatic and aromatic nitrile oxides and a variety of homoallylic alcohols participate in the cycloaddition, thus expanding the scope of polyketide building blocks that can be accessed using this strategy.
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