Renal elimination of verbenols in man following experimental alpha-pinene inhalation exposure
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J O Levin1, K Eriksson, A Falk
1National Institute of Occupational Health, Umeå, Sweden.
International Archives of Occupational and Environmental Health
|January 1, 1992
Abstract:
The renal elimination of verbenols after experimental exposure to (+) and (-)alpha-pinene was studied in humans following exposure to 10, 225, and 450 mg.m-3 terpene in an exposure chamber. The pulmonary uptake was about 60%. About 8% was eliminated unchanged in exhaled air. Depending on the exposure level, about 1%-4% of the total uptake was eliminated as cis- and trans-verbenol. Most of the verbenols were eliminated within 20 h after a 2-h exposure. The renal excretion of unchanged alpha-pinene was less than 0.001%.