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Pediatric epilepsy -- an Indian perspective
1Grant Medical College & JJ Group of Hospitals, PD Hinduja National Hospital and BJ Wadia Hospital for Children, Mumbai, India. vrajesh@vsnl.com
Insights
Epilepsy prevalence in India mirrors developed nations, with neurocysticercosis (NCC) as a primary cause. Significant treatment gaps persist, highlighting a public health challenge for epilepsy management.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Epilepsy prevalence in India is comparable to developed countries.
- Neurocysticercosis (NCC) is a leading cause of epilepsy in India.
- A substantial treatment gap remains a significant public health concern.
Purpose of the Study:
- To review the epidemiology and etiology of epilepsy in India.
- To highlight the challenges in epilepsy treatment and management.
- To discuss specific etiologies like NCC and neonatal hypoglycemic brain injury.
Main Methods:
- Review of existing prevalence studies on epilepsy in India.
- Analysis of etiological factors, particularly neurocysticercosis.
- Examination of risk factors for intractable epilepsy (IE).
Main Results:
- Epilepsy prevalence is similar to developed nations; NCC is the predominant etiology.
- Benign epilepsies and West syndrome are underrepresented in classification studies.
- Intractable epilepsy risk factors include early onset and neurodevelopmental issues; many cases are treatable.
Conclusions:
- Addressing the treatment gap for epilepsy in India is crucial.
- Neurocysticercosis and neonatal brain injury are key areas for intervention.
- Many cases of presumed intractable epilepsy can be managed with appropriate therapies.
Abstract:
Prevalence studies from India suggest that epilepsy prevalence is similar to developed nations. Neurocysticercosis (NCC) predominates as an etiology. A large treatment gap is still a public health problem. Benign epilepsies and West syndrome appear to be underrepresented in studies on classification of seizures/syndromes. Febrile seizures prevalence in India is similar to other countries and appear to be as benign. Risk factors of intractable epilepsy (IE) in Indian studies include early age of onset, neurodevelopmental abnormalities and certain seizure types. Perinatal injuries underlie many IE. Many IE are not truly intractable and respond to simple therapeutic measures. The ketogenic diet and surgery are other methods now being used in Indian centers. Neurocysticercosis and neonatal hypoglycemic brain injury, two widely prevalent etiologies are reviewed in detail.
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