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Published on: September 22, 2020

Suboptimal treatment of risk factor for atherosclerosis in critical limb ischemia

J Barani1, I Mattiasson, B Lindblad

  • 1Department of Vascular Diseases, University of Lund, Malmö University Hospital, Malmö, Sweden. jamal.barani@skane.se

International Angiology : a Journal of the International Union of Angiology
|May 7, 2005
PubMed

Insights

Critical limb ischemia (CLI) affects 38 per 100,000 people annually. Many CLI patients have uncontrolled risk factors like high blood pressure and cholesterol, indicating suboptimal treatment for this high-risk group.

Area of Science:

  • Vascular Medicine
  • Epidemiology
  • Cardiovascular Disease

Background:

  • Critical limb ischemia (CLI) epidemiology requires further study.
  • Risk factor management in CLI patients is less emphasized than in other atherosclerotic conditions.
  • Understanding CLI incidence and risk factor control in Sweden is crucial.

Purpose of the Study:

  • To determine the incidence of critical limb ischemia (CLI) in Sweden.
  • To assess the quality of risk factor treatment in Swedish CLI patients.
  • To identify the prevalence of modifiable risk factors in CLI patients.

Main Methods:

  • A 14-month observational study of 316 consecutive CLI patients in Malmo, Sweden.
  • Evaluation of intercurrent diseases, medications, blood pressure, glucose, lipids, homocysteine, cardiolipin antibodies, and APC-resistance.
  • Inclusion of 259 patients (82%) who consented to detailed assessment.

Main Results:

  • CLI incidence was 38 per 100,000 inhabitants per year.
  • 53% of patients had uncontrolled blood pressure and 48% had uncontrolled lipid levels.
  • Only 24% met national guidelines for both blood pressure and lipid management; 47% had prior myocardial infarction/angina.

Conclusions:

  • CLI patients exhibit significant comorbidity with vascular diseases.
  • A high prevalence of modifiable atherosclerotic risk factors exists in this population.
  • Evidence-based medical therapy for CLI patients is suboptimal.
Abstract

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