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Published on: January 3, 2018
Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics
Mario Alvarado1, Alberto Coelho, Christian F Masaguer
1Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela. E-15782, Santiago de Compostela, Spain.
Abstract:
A series of 3-aminoethyl-1-tetralones, conformationally constrained higher homologues of haloperidol (standard for typical antipsychotic profile), have been obtained by a four-step route from valerolactone. Their binding affinities at dopamine D(2) and serotonin 5-HT2A and 5-HT2C receptors were determined, showing in some cases an atypical antipsychotic profile.
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