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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Multiple autoantigen mimotopes of infectious agents induce autoimmune arthritis and uveitis in lewis rats
Gerhild Wildner1, Maria Diedrichs-Moehring
1Section of Immunobiology, Dept. of Ophthalmology, Ludwig-Maximilians-University, Mathildenstr. 8, 80336 Munich, Germany. Gerhild.Wildner@med.uni-muenchen.de
Clinical and Diagnostic Laboratory Immunology
|May 10, 2005
Abstract:
We found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from several other "self" or foreign antigens sharing amino acid sequence homologies. Many of these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats, indicating a role for multiple antigens in the initiation of a certain autoimmune disease.
