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Updated: Aug 18, 2026

CRISPR-Mediated Reorganization of Chromatin Loop Structure
Published on: September 14, 2018
Developmental regulation of the beta-globin gene locus
Lyubomira Chakalova1, David Carter, Emmanuel Debrand
1Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge, CB2 4AT, UK.
Abstract:
The beta-globin genes have become a classical model for studying regulation of gene expression. Wide-ranging studies have revealed multiple levels of epigenetic regulation that coordinately ensure a highly specialised, tissue- and stage-specific gene transcription pattern. Key players include cis-acting elements involved in establishing and maintaining specific chromatin conformations and histone modification patterns, elements engaged in the transcription process through long-range regulatory interactions, transacting general and tissue-specific factors. On a larger scale, molecular events occurring at the locus level take place in the context of a highly dynamic nucleus as part of the cellular epigenetic programme.
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