Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Receptor selection and B cell immune tolerance].

Bing Hu1, Yuquan Wei

  • 1Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, People's Republic of China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|May 12, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Correlation between prostatic parameters of transrectal ultrasonography and age in patients with benign prostatic hyperplasia].

Zhonghua nan ke xue = National journal of andrology·2018
Same author

Preoperative Transurethral Contrast-Enhanced Ultrasonography in the Diagnosis of Female Urethral Diverticula.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine·2018
Same author

Successful endoscopic removal of a rare, large impacted pancreatic duct stone using grasping forceps: A case report with video.

Medicine·2018
Same author

Circadian genes period1b and period2 differentially regulate inflammatory responses in zebrafish.

Fish & shellfish immunology·2018
Same author

Zebrafish Lacking Circadian Gene <i>per2</i> Exhibit Visual Function Deficiency.

Frontiers in behavioral neuroscience·2018
Same author

Gender, age, and concomitant diseases of melanosis coli in China: a multicenter study of 6,090 cases.

PeerJ·2018

Immune self-tolerance relies on receptor selection, not just cell deletion. Secondary gene rearrangement shapes immune responses and prevents self-destruction by autoreactive lymphocytes.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Context:

  • Mammalian immune systems combat diverse antigens via V, D, J gene rearrangement.
  • Immune self-tolerance prevents autoreactive lymphocytes from causing self-destruction.
  • Previously, cell or clone selection was thought to maintain self-tolerance.

Purpose:

  • To investigate the role of receptor selection in immune self-tolerance.
  • To explore the mechanism of secondary gene rearrangement in lymphocytes.
  • To understand how receptor editing shapes immune responses.

Summary:

  • Recent findings indicate receptor selection, via secondary gene rearrangement, is crucial for immune self-tolerance.
  • This process occurs at various lymphocyte differentiation stages.

Related Experiment Videos

  • Secondary rearrangement also modifies receptor specificity post-antigen interaction, influencing immune responses.

    • Impact:

    • Challenges the traditional view of cell selection in self-tolerance.
    • Highlights a novel mechanism for maintaining immune homeostasis.
    • Provides insights into adaptive immunity and autoimmune disease prevention.