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Updated: Jul 20, 2026
09:14
DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments
Published on: January 27, 2016
The epigenome network of excellence
Asifa Akhtar1, Giacomo Cavalli
1European Molecular Biology Laboratory in Heidelberg, Germany. asifa.akhtar@embl.de
Plos Biology
|May 12, 2005
Summary
A European Union initiative fosters collaboration between research groups to address critical questions in epigenetics. This network aims to advance the field through shared expertise and resources.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Epigenetics is crucial for understanding gene regulation and cellular processes.
- Existing research networks may lack comprehensive scope or interdisciplinary connections.
Purpose of the Study:
- To establish a collaborative European network for epigenetics research.
- To foster synergy between established and early-career investigators.
- To address fundamental questions in the field of epigenetics.
Main Methods:
- Formation of a collaborative research network.
- Integration of established and younger research groups.
- Focus on key questions in epigenetics.
Main Results:
- A new collaborative network is being built.
- Established and younger research groups are participating.
- Key epigenetics questions are being targeted.
Conclusions:
- The initiative facilitates intergenerational knowledge transfer in epigenetics.
- Collaborative efforts are expected to accelerate discoveries in epigenetics.
- This network strengthens the European research landscape in epigenetics.
Related Concept Videos
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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03:17Inheritance of Chromatin Structures
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
01:37Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...