Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Study on HLA system in IgA nephropathy.

K Komori, Y Nose, H Inouye

    Tissue Antigens
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Subgroups A and B respiratory syncytial virus isolated in Ehime Prefecture, 1995-1999.

    Japanese journal of infectious diseases·2001
    Same author

    Sensitive detection of Cryptosporidium oocysts in environmental water samples by reverse transcription-PCR.

    Japanese journal of infectious diseases·2001
    Same author

    Histidine residues underlie Congo red binding to A beta analogs.

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2000
    Same author

    A beta fibrillogenesis: kinetic parameters for fibril formation from congo red binding.

    Journal of structural biology·2000
    Same author

    Betabellins 15D and 16D, de Novo designed beta-sandwich proteins that have amyloidogenic properties.

    Journal of structural biology·2000
    Same author

    Structural changes in a hydrophobic domain of the prion protein induced by hydration and by ala-->Val and pro-->Leu substitutions.

    Journal of molecular biology·2000

    This study found a significant association between IgA nephropathy and a specific gene marker in the HLA-D region in Japanese patients. This suggests a genetic link to this kidney disease.

    Area of Science:

    • Immunogenetics
    • Nephrology
    • Human Leukocyte Antigen (HLA) system

    Background:

    • IgA nephropathy is a common form of glomerulonephritis.
    • Genetic factors are implicated in the pathogenesis of IgA nephropathy.
    • Previous studies have explored associations with various HLA regions.

    Purpose of the Study:

    • To investigate the association between specific Human Leukocyte Antigen (HLA) alleles and IgA nephropathy in a Japanese cohort.
    • To determine if HLA-A, HLA-B, or HLA-D region genes are more strongly linked to IgA nephropathy.

    Main Methods:

    • Human Leukocyte Antigen (HLA) typing for HLA-A and HLA-B was performed on 40 Japanese IgA nephropathy patients.
    • HLA-D typing was conducted on 37 patients using homozygous cells related to DRw6.

    Related Experiment Videos

  • Patient controls (n=46) with chronic hemodialysis and normal controls (n=115) were included for comparison.

    • Main Results:

    • A significantly increased frequency of HLA-DEn (related to DRw6) was observed in 46% of IgA nephropathy patients compared to 18.3% in normal controls (P < 0.0007).
    • HLA-B12 showed a high occurrence (27.5%) but was not statistically significant.
    • The association with the HLA-D region was more pronounced than with HLA-A or HLA-B regions.

    Conclusions:

    • The findings suggest a genetic predisposition to IgA nephropathy associated with the HLA-D region in the studied Japanese population.
    • The HLA-D region appears to play a more significant role in IgA nephropathy susceptibility than HLA-A or HLA-B.
    • Further research into specific HLA-D alleles may elucidate the underlying mechanisms of IgA nephropathy.