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Dual-action penems and carbapenems
A J Corraz1, S L Dax, N K Dunlap
1Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
Journal of Medicinal Chemistry
|May 15, 1992
Abstract:
Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.