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The effect of creatine intake on renal function.
1College of Pharmacy, Ferris State University, Big Rapids, MI, USA.
The Annals of Pharmacotherapy
|May 12, 2005
Summary
Creatine supplementation minimally affects kidney function and creatinine levels in healthy young adults. Long-term use shows limited impact on creatinine clearance, suggesting safety for this population.
Area of Science:
- Sports Nutrition
- Nephrology
- Exercise Physiology
Background:
- Creatine supplementation is popular among athletes.
- Concerns exist regarding its impact on renal function.
- Creatine is metabolized to creatinine in the body.
Purpose of the Study:
- To evaluate the effects of creatine supplementation on kidney function.
- To assess the impact on creatinine clearance estimates.
Main Methods:
- Conducted a MEDLINE literature search (1966-2004).
- Included studies on creatine, creatinine, kidney function, toxicity, and exercise.
- Cross-referenced relevant articles for comprehensive data.
Main Results:
- Creatine supplementation slightly elevates creatinine concentrations, but not clinically significantly.
- Both acute and chronic creatine ingestion showed minimal impact on renal function in healthy young adults.
- Longer-term supplementation (up to 5.6 years) had a limited effect on creatinine levels.
Conclusions:
- Creatine supplementation appears safe for renal function and creatinine clearance in young, healthy individuals.
- Observed increases in creatinine are minimal and unlikely to affect clinical assessments.
- Further research is needed in elderly populations and individuals with kidney insufficiency.