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Updated: May 27, 2026
10:12
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Tigecycline penetration into skin and soft tissue
Gary E Stein1, Curtis L Smith, Anne Missavage
1Department of Medicine, Michigan State University , East Lansing, Michigan, USA. steing@msu.edu
Surgical Infections
|December 6, 2011
Summary
Tigecycline concentrations were higher in skin and soft tissue (SST) than in serum for patients with complicated skin and soft tissue infections (cSSTIs). This study provides key data on tigecycline
Area of Science:
- Pharmacokinetics and Pharmacodynamics
- Infectious Diseases
- Dermatology
Background:
- Tigecycline, a minocycline derivative, exhibits activity against pathogens common in complicated skin and soft tissue infections (cSSTIs), including MRSA.
- Limited data exists regarding tigecycline's penetration into skin and soft tissue (SST).
Purpose of the Study:
- To evaluate tigecycline penetration into SST in patients with cSSTIs.
- To determine tissue and serum concentrations of tigecycline over time.
Main Methods:
- Twenty-five patients with cSSTIs requiring surgery received tigecycline (100-mg loading dose, then 50-mg every 12 hours).
- Blood and SST samples were collected at various time points post-infusion for concentration analysis.
- Tissue-to-serum concentration ratios were calculated at 2-4, 5-7, and 8-10 hours post-infusion.
Main Results:
- Mean serum peak and trough concentrations of tigecycline were 0.56±0.25 mg/L and 0.26±0.12 mg/L, respectively.
- Mean tissue:serum ratios ranged from 2.8 to 5.2 across the evaluated time intervals.
- Higher tigecycline concentrations were consistently observed in SST compared to serum.
Conclusions:
- Tigecycline demonstrates significant penetration into skin and soft tissue.
- The findings support the use of tigecycline for treating cSSTIs, showing favorable tissue concentrations.
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