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Updated: Aug 18, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
Common interleukin 10 polymorphism associated with decreased risk of tuberculosis
Hyoung Doo Shin1, Byung Lae Park, Young Hyo Kim
1Department of Genetic Epidemiology, SNP Genetics, Inc.11th Floor, MaeHun B/D, 13 Jongro 4 ga, Jongro-gu, Seoul 110-834, Korea.
Abstract:
Interleukin 10 (IL10) is a powerful TH2-cell cytokine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clinical manifestations of tuberculosis (TB) were examined in a large number of patients with clinical TB infection (n = 459) and normal controls (n = 871). One common promoter SNP (IL10 -592 A>C) was found to be significantly associated with decreased risk of TB manifestation. The frequency of the "C"-bearing genotype was higher in normal controls than in patients with clinical TB infection (P = 0.005, OR = 0.69). A summary of the genetic effect of IL10 -1082 A>G, the other nearby promoter SNP, in other ethnic groups is also presented.
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