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Updated: Aug 18, 2026
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Murine model of invasive aspergillosis
Russell E Lewis1, Nathan P Wiederhold
1The Department of Clinical Sciences and Administration, The University of Houston College of Pharmacy and The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Abstract:
The growing importance of infectious caused by Aspergillus species during the last decade has created a need for practical and reproducible animal models of invasive aspergillosis suitable for studying fungal virulence, infection pathogenesis, diagnostic markers, and testing of antifungal therapy. Murine models remain the most commonly used models for studying aspergillosis because of their ease of manipulation and the large number of reagents available for studying disease-host responses. This chapter provides describes a murine model of invasive aspergillosis suitable for basic and translational studies of invasive pulmonary aspergillosis and highlights experimental variables that affect the course and reproducibility of infection.
Insights
This study details a reproducible murine model for invasive aspergillosis, crucial for understanding fungal infections and testing new antifungal treatments. The model aids research into Aspergillus virulence and pathogenesis.
Area of Science:
- Mycology
- Infectious Diseases
- Animal Models
Background:
- Invasive aspergillosis is an increasing threat, necessitating robust experimental models.
- Murine models are preferred for aspergillosis research due to accessibility and available reagents.
Purpose of the Study:
- To describe a practical and reproducible murine model for invasive pulmonary aspergillosis.
- To aid basic and translational research on fungal virulence, pathogenesis, diagnostics, and antifungal therapy.
Main Methods:
- Utilizes a murine model for invasive pulmonary aspergillosis.
- Highlights key experimental variables impacting infection course and reproducibility.
Main Results:
- Presents a standardized protocol for a murine model of invasive aspergillosis.
- Identifies critical factors influencing infection outcomes in the model.
Conclusions:
- The described murine model is suitable for studying invasive pulmonary aspergillosis.
- This model supports research into fungal pathogenesis and therapeutic strategies.
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