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[Meta-analysis of postoperative adjuvant chemotherapy for Dukes' B colorectal carcinoma]
Xiang-Bin Wan1, Zhi-Zhong Pan, Gong Chen
1Department of Abdominal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China. zzpan@21cn.com.
Background & Objective:
The necessity of adjuvant chemotherapy after radical surgery for patients with Dukes' B (stage II) colorectal carcinoma remains controversial. This study was to evaluate effect of postoperative adjuvant chemotherapy on survival of Dukes' B patients with meta-analysis.
Methods:
The results of literatures on postoperative adjuvant chemotherapy for Dukes' B patients from 1985 to 2003 were analyzed synthetically.The 5-year survival rates of postoperative adjuvant chemotherapy group and surgery alone group were compared.
Results:
Eight published randomized controlled trails were eligible, and had 6 518 patients totally. The 5-year mortality was lower in postoperative adjuvant chemotherapy group than in surgery alone group with odds ratio (OR) of 0.79, and 95% confidence interval (CI) of 0.7-0.9, (P<0.05).
Conclusion:
Postoperative adjuvant chemotherapy could improve 5-year survival rate of Dukes' B patients.
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