Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement before molecular biology.

Peter Lachmann1

  • 1Emeritus Sheila Joan Smith Professor of Immunology, University of Cambridge, Centre for Veterinary Science, Madingley Road, Cambridge CB3 0ES, UK. pjl1000@cam.ac.uk

Molecular Immunology
|May 14, 2005
PubMed
Summary

The complement system, discovered in the 1890s, is a complex biological pathway. This review details its research history, focusing on the 1964 CIBA symposium and the impact of molecular biology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systems leadership for quality in health care: from principles to actions.

International journal for quality in health care : journal of the International Society for Quality in Health Care·2026
Same author

Clinical validation of noninvasive blood glucose measurements by midinfrared spectroscopy.

Communications medicine·2025
Same author

Systemic ß adrenergic stimulation/ sympathetic nerve system stimulation influences intraocular RAS through cAMP in the RPE.

Experimental eye research·2019
Same author

Renin cells with defective Gsα/cAMP signaling contribute to renal endothelial damage.

Pflugers Archiv : European journal of physiology·2019
Same author

Universal health coverage and intersectoral action for health: key messages from Disease Control Priorities, 3rd edition.

Lancet (London, England)·2017
Same author

Interference with Gs<i>α</i>-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage.

Journal of the American Society of Nephrology : JASN·2017

Area of Science:

  • Immunology
  • Biochemistry

Background:

  • The complement system, a critical component of innate immunity, has been studied since the late 19th century.
  • Its intricate mechanisms involve a cascade of proteins essential for host defense.
  • Early research laid the groundwork for understanding this complex biological system.

Observation:

  • The 1964 CIBA symposium on Complement served as a pivotal moment in the field.
  • This review reflects on the historical perspectives and research experiences surrounding complement.
  • The advent of molecular biology in the 1980s significantly advanced complement research.

Findings:

  • The historical trajectory of complement research reveals a gradual elucidation of its multifaceted roles.
  • Key milestones, including significant symposia, mark the progression of scientific understanding.
  • The integration of molecular biology revolutionized the study of complement pathways.

Implications:

  • Understanding the history of complement research provides context for current immunological studies.
  • The evolution of research methodologies has enhanced our ability to study immune system components.
  • Continued investigation into the complement system holds promise for therapeutic advancements.

Related Experiment Videos