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Characterization of an RFamide-related peptide orphan GPCR in C. elegans

I Mertens1, A Vandingenen, E Clynen

  • 1Laboratory of Developmental Physiology, Genomics, and Proteomics, Katholieke Universiteit Leuven, Belgium. inge.mertens@bio.kuleuven.ac.be

Annals of the New York Academy of Sciences
|May 14, 2005
PubMed

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Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...