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Updated: Aug 18, 2026

Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity
Published on: February 17, 2017
Structure and biological activity of heparinoid
Neeraj Kumar1, A Bentolila, A J Domb
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar 060-062, India.
Abstract:
Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective anti-metastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.
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