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[Cellular immune reactivity in patients with multiple myeloma]
Acta Medica Austriaca
|January 1, 1978
Summary
Multiple myeloma patients show reduced lymphocyte transformation rates due to inherent defects. Increased suppressor cell activity in these patients correlates with lower IgM levels.
Area of Science:
- Immunology
- Hematology
- Cell Biology
Context:
- Multiple myeloma is a cancer of plasma cells.
- Altered immune function is common in multiple myeloma patients.
Purpose:
- To investigate lymphocyte reactivity in multiple myeloma patients.
- To identify the underlying causes of immune dysfunction.
Summary:
- Lymphocyte transformation rates induced by ConA, PHA, and PWM were significantly decreased in 19 multiple myeloma patients.
- The findings suggest lymphocyte-inherent defects, not serum factors, are responsible for reduced reactivity.
- Pathologically increased ConA-induced suppressor cell activity was observed in 58% of patients, negatively correlated with non-paraprotein IgM concentration.
Impact:
- Provides insights into the immunological defects in multiple myeloma.
- Suggests potential therapeutic targets for immune modulation in multiple myeloma.