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Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro
Ye-Gao Chen1, Zheng-Cai Wu, Shi-Hong Gui
1Department of Chemistry, Yunnan Normal University, Kunming, Yunnan 650092, China. ygchen48@hotmail.com
Fitoterapia
|May 17, 2005
Abstract:
The lignans, gomisin G (1), schisantherin A (2), benzoylgomisin Q (3) and isoanwulignan (4) were isolated from the stems of Schisandra henryi. Compound 1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound 1 represents a new type of DNA strand scission agent.