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Updated: Aug 18, 2026
Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
Published on: December 14, 2014
Prepubertal chronic ethanol administration alters TTF-1 and Oct-2 expression in the hypothalamus of female rats
Hyun Joon Kim1, Hyun Joon Sohn, Myung Ha
1Department of Anatomy and Neurobiology, Institute of Health Sciences, College of Medicinem, Gyeongsang National University, 92 Chilam-dong, Jinju 660-751, South Korea.
Abstract:
We found that prolonged administration of ethanol (3 g/kg i.p. at 08:00, once per day) to young female rats starting on postnatal day 24 caused delayed puberty. We further found that prolonged ethanol administration changed the typical hypothalamic expression patterns of TTF-1 and Oct-2 and reduced GnRH mRNA expression. We suggest that these changes may cause the ethanol-induced disturbances in the regulation of GnRH in the hypothalamus and may be responsible for the ethanol-induced reduction in GnRH and LH associated with delayed puberty.
