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Buffer effects on swelling kinetics in polybasic gels.

R A Siegel1, I Johannes, C A Hunt

  • 1Department of Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0446.

Pharmaceutical Research
|January 1, 1992
PubMed
Summary
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Polybasic gels exhibit pH-dependent swelling, primarily influenced by non-ionized buffer concentration rather than direct pH changes. This limits their use in controlled oral drug release applications.

Area of Science:

  • Polymer Science
  • Materials Science
  • Physical Chemistry

Background:

  • Polybasic gels, copolymers of methyl methacrylate and dimethylaminoethyl methacrylate, display pH-sensitive swelling behavior.
  • Understanding swelling kinetics is crucial for applications involving controlled release.
  • The influence of buffer properties on gel swelling requires detailed investigation.

Purpose of the Study:

  • To investigate the swelling kinetics of polybasic gels in acidic solutions.
  • To determine the effects of solution pH, buffer pKa, and buffer concentration on gel swelling rates.
  • To elucidate the mechanism underlying the pH sensitivity of these polybasic gels.

Main Methods:

  • Swelling kinetics of polybasic gels were studied in acidic buffer solutions.

Related Experiment Videos

  • The concentration of non-ionized buffer was calculated using the Henderson-Hasselbach equation.
  • Effects of pH, buffer pKa, and concentration on swelling rate were systematically assessed.

    • Main Results:

    • Gel swelling rate demonstrated a near-linear dependence on the concentration of non-ionized buffer.
    • The primary driver for pH sensitivity was identified as the effect of pH on non-ionized buffer concentration.
    • Proton availability, carried by non-ionized buffers to gel amines, dictates swelling.

    Conclusions:

    • The pH sensitivity of these polybasic gels is mainly governed by the non-ionized buffer concentration.
    • These gels may not be suitable for reliable pH-sensitive swelling-controlled release in oral applications due to uncontrolled stomach conditions.
    • The gels can serve as pH-triggered release mediators where precise rate control is not critical.