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The clinical application of proteomics.
David A Colantonio1, Daniel W Chan
1Department of Pathology, Clinical Chemistry Division, Johns Hopkins Medical Institutions, 600 North Wolfe Street/Meyer B-121, Baltimore, MD 21287-7065, USA.
Summary
Proteomics, the study of proteins, offers insights into disease mechanisms. This review highlights the clinical applications and challenges of proteomic research in medicine.
Area of Science:
- Biochemistry and Molecular Biology
- Medical Science
Background:
- Proteomics involves the large-scale study of proteins to understand cellular functions.
- Researchers utilize proteomic technology to identify protein alterations in healthy versus diseased states.
Purpose of the Study:
- To review the clinical applications of proteomics.
- To emphasize current practical issues and challenges in proteomic research.
Main Methods:
- Review of existing literature on proteomic techniques and strategies in medicine.
- Analysis of the complexities and challenges in serum proteomic analysis.
Main Results:
- Proteomic techniques are transforming biomarker discovery in medicine.
- Serum complexity presents both opportunities and significant challenges for proteomic applications.
Conclusions:
- Proteomics holds great promise for clinical applications.
- Addressing practical issues and challenges is crucial for advancing proteomic research in medicine.