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Updated: Aug 18, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
Published on: January 14, 2014
[Extra-cranial anaplastic oligoastrocytoma development from a low-grade glioma]
Jorge Molina Saera1, Angel Segura Huerta, Laura Palomar Abad
1Servicio de Oncología Médica, Hospital Universitario La Fe, Avda. Campanar 21, 46009 Valencia, Spain. segura_ang@gva.es
Abstract:
Oligodendrogliomas are primary brain tumours derived from oligodendroglial cells, or precursors, and represent 2%-5% of brain tumours. This type of glioma has a favourable prognosis compared to other brain tumours. The treatment is multidisciplinary and is based on three therapeutic arms: surgery, radiotherapy and chemotherapy. We present a patient who had received treatment previously for a lowgrade glioma and who subsequently developed an anaplastic oligoastrocytoma in the same zone together with skull and extra-cranial involvement in the disease progression.

