Related Experiment Video
Updated: Aug 18, 2026
11:09
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41
Florence M Brunel1, Philip E Dawson
1The Scripps Research Institute, Department of Chemistry and Cell Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Chemical Communications (Cambridge, England)
|May 19, 2005
Abstract:
We present a straightforward and high yielding method to synthesize constrained helical peptides via thioether ligation; this method represents an attractive alternative to the formation of lactam bridge constraints to induce helicity in peptides.
