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Updated: Aug 9, 2026

Expression Analysis of Mammalian Linker-histone Subtypes
Published on: March 19, 2012
Metazoan replication-dependent histone mRNAs: a distinct set of RNA polymerase II transcripts
1Program in Molecular Biology and Biotechnology, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, North Carolina 27599, USA. marzluff@med.unc.edu
Abstract:
Metazoan replication-dependent histone mRNAs are the only eukaryotic mRNAs that lack polyA tails. The genes for the five histone proteins have remained physically linked during evolution. Expression of histone mRNAs and histone proteins requires a unique set of factors, and may be coordinated by association of the histone genes with Cajal bodies. Recently several novel factors, including components of the U7 snRNP, as well as proteins involved in regulation of histone gene expression, have been described.
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