Related Experiment Videos
Buccal misoprostol to prevent hemorrhage at cesarean delivery: a randomized study
Jennifer Hamm1, Zoi Russell, Tracey Botha
1Arnold Palmer Hospital for Children and Women, Orlando, Fla, USA.
Objective:
The purpose of this study was to assess the efficacy of buccal misoprostol to decrease uterine atony, hemorrhage, and the need for additional uterotonic agents during cesarean delivery.
Study Design:
Patients who underwent cesarean delivery were assigned randomly to either 200-microg misoprostol or placebo placed in the buccal space. A dilute intravenous oxytocin infusion was given to all patients at delivery of the placenta. The primary outcome variable was the need for additional uterotonic agents.
Results:
A total of 352 women received random assignments. Demographic and intrapartum characteristics were similar between the groups. More women in the placebo group required 1 additional uterotonic agent (43% vs 26%; P < .01; relative risk, 1.3; 95% CI, 1.10, 1.50). There was not a difference between the groups in the incidence of postpartum hemorrhage or a difference in preoperative and postoperative hemoglobin level.
Conclusion:
Buccal misoprostol reduces the need for additional uterotonic agents during cesarean delivery.
