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Updated: Aug 11, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
Published on: August 17, 2022
Compromised arterial oxygen saturation in elderly asthma sufferers results in selective cognitive impairment
Mark Moss1, Mark Franks, Pamela Briggs
1Human Cognitive Neuroscience Unit, Division of Psychology, University of Northumbria, Newcastle-upon-Tyne, UK. mark.moss@unn.ac.uk
Abstract:
Forty elderly patients with asthma or chronic obstructive pulmonary disorder (COPD) were compared to a comparison group of forty age-matched healthy volunteers on a range of measures of cognitive performance, and levels of arterial haemoglobin oxygen saturation recorded. Members of the patient group were found to have significantly lower oxygen saturation compared to the comparison group, and performed significantly poorer on tests of delayed word recall and serial subtractions, but not on other tasks. Correlational analysis between participants' oxygen saturation levels and test scores across the whole sample indicated significant positive relationships existed for the digit symbol substitution and serial subtractions tasks. The results are discussed in terms of cerebral oxygen delivery, glucose metabolism, age related cognitive decline, and relative task demands.
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