Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonequilibrium model for estimating parameters of deleterious mutations.

Isabel Gordo1, Francisco Dionisio

  • 1Instituto Gulbenkian de Ciencia, Rua Quinta Grande, Oeiras, Portugal. igordo@gulbenkian.pt

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|May 21, 2005
PubMed
Summary

Deleterious mutations are crucial for evolutionary variability but their rates and fitness effects are unknown. This study presents a simple model to quantify these values in microorganisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and Environmental Plasmids: Antibiotic Resistance, Virulence, Mobility, and ESKAPEE Pathogens.

Antibiotics (Basel, Switzerland)·2026
Same author

From nature or from a laboratory? Science, health, and politics in the dispute over the origin of SARS-CoV-2.

Historia, ciencias, saude--Manguinhos·2026
Same author

Plasmid Genomic Dynamics and One Health: Drivers of Antibiotic Resistance and Pathogenicity.

Pathogens (Basel, Switzerland)·2025
Same author

Aging: a possible road toward gut microbiota pathoadaptation.

Gut microbes·2025
Same author

Clonal interference and genomic repair during strain coexistence in the gut.

PLoS genetics·2025
Same author

Evolution of Escherichia coli strains under competent or compromised adaptive immunity.

PLoS pathogens·2025

Area of Science:

  • Evolutionary biology
  • Population genetics

Background:

  • Deleterious mutations are essential for maintaining genetic variability in populations.
  • Understanding mutation rates and their fitness impact is critical for evolutionary studies.
  • These mutations pose risks to small, asexual populations and influence sexual reproduction.

Purpose of the Study:

  • To develop a simple model for quantifying deleterious mutation rates.
  • To estimate the fitness effects of individual mutations.
  • To enable application in experimental settings, particularly with microorganisms.

Main Methods:

  • Analysis of a simplified mathematical model.
  • Designed for application in experimental evolution studies.
  • Focus on microorganisms for practical quantification.

Related Experiment Videos

Main Results:

  • The model provides a framework for estimating key evolutionary parameters.
  • Enables quantification of deleterious mutation rate.
  • Facilitates estimation of fitness effects per mutation.

Conclusions:

  • The proposed model offers a tractable approach to study deleterious mutations.
  • Aims to improve understanding of evolutionary dynamics driven by mutation.
  • Provides tools for experimental validation in microbial systems.