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Evaluation of the automated coagulation analyzer Sysmex CA-7000
Alexandra Dorn-Beineke1, Carl-Erik Dempfle, Thomas Bertsch
1Institute for Clinical Chemistry, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany. alexandra.dorn-beineke@ikc.ma.uni-heidelberg.de
Thrombosis Research
|May 24, 2005
Summary
The Sysmex CA-7000 analyzer offers excellent analytical performance and significantly faster throughput for coagulation testing. It is well-suited for high-volume labs handling diverse sample types, demonstrating reliable results with minimal interference.
Area of Science:
- Clinical diagnostics
- Hematology
- Laboratory automation
Background:
- Centralized laboratories require high-throughput analyzers for efficient coagulation testing.
- Increasing urgent and nonstandard samples necessitate analyzers with short turnaround times.
- The Sysmex CA-7000 is a new analyzer for coagulation diagnostics.
Purpose of the Study:
- To evaluate the analytical and technical performance of the Sysmex CA-7000 coagulation analyzer.
- To assess its suitability for routine laboratory conditions with high sample volumes.
Main Methods:
- Comparative analysis of Sysmex CA-7000 against Sysmex CA-6000 for PT, INR, aPTT, Clauss fibrinogen, and derived fibrinogen.
- Comparison of antithrombin (AT) measurements with Dimension RxL.
- Evaluation of imprecision, throughput, STAT functions, and routine sample handling.
Main Results:
- Sysmex CA-7000 demonstrated very low intra-assay and inter-assay variability for all tested coagulation parameters.
- Good comparability was observed when compared to Sysmex CA-6000 and Dimension RxL analyzers.
- Throughput was 2.5–3 times faster than Sysmex CA-6000; interference noted with high bilirubin and triglyceride levels.
Conclusions:
- The Sysmex CA-7000 is the first published evaluation of its analytical and technical performance.
- The analyzer is well-suited for high-throughput coagulation laboratories.
- It effectively handles a high number of nonstandard samples, meeting laboratory demands.