Related Experiment Video
Updated: Aug 17, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Depressive symptoms predict slow cognitive decline in mild dementia
J G E Janzing1, P Naarding, P Eling
1Department of Psychiatry, Radboud University Nijmegen Medical Centre; the Nijmegen Institute for Cognition and Information, Apeldoorn, The Netherlands. j.janzing@psy.umcn.nl
Abstract:
Depression may be a prognostic marker of subsequent cognitive decline in patients with dementia. Earlier investigations did not find support for this hypothesis, but these considered mainly syndromal depression. In this prospective study, 32 subjects with mild dementia were followed up for 12 months. The effects of GMS-AGECAT syndromal depression, subsyndromal depression and dimensions of depressive symptoms were studied. Higher levels of mood symptoms but not (sub)syndromal depression predicted slower cognitive decline during follow-up. It is hypothesized that the report of depressive symptoms by subjects with mild dementia reflects relative intactness of cognitive functions, not accounted for by cognitive screening instruments.
Related Concept Videos
Dementia l: Introduction
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Dementia
The progression of dementia is generally gradual.
Alzheimer Disease l: Introduction
Depressive Disorders: MDD and Dysthymia
Cognitive Development During Adulthood

