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Updated: Aug 9, 2026

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
Published on: January 21, 2020
A novel stent for treatment of combined anterior glottic web-subglottic stenosis
1Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Johns Hopkins Outpatient Center, Room 6231, 601 North Caroline Street, Baltimore, MD 21287-0910, USA. dtunkel@jhmi.edu
Insights
Severe congenital glottic webs combined with subglottic stenosis were treated using a novel stent. This innovative approach in two young children led to successful decannulation and improved vocal quality.
Area of Science:
- Otolaryngology
- Pediatric Surgery
- Respiratory Medicine
Background:
- Congenital glottic webs frequently coexist with subglottic stenosis, posing significant airway challenges.
- Surgical management of combined anterior glottic web and subglottic stenosis requires innovative solutions for airway patency and reconstruction.
Observation:
- Two young patients presented with severe congenital glottic webs and associated subglottic stenosis.
- A novel stent, fashioned from a modified tracheal T-tube, was employed as both a subglottic stent and a glottic keel.
Findings:
- The surgical technique involved partial laryngofissure and anterior costal cartilage grafting.
- The novel stent effectively maintained airway patency and supported glottic reconstruction in both cases.
- Both children were successfully decannulated post-operatively, indicating a positive outcome.
Implications:
- This combined surgical approach and novel stent design offer a promising treatment for complex pediatric airway stenosis.
- The findings suggest a potential for improved vocal function and reduced long-term morbidity in affected children.
- Further research into this stent design could refine surgical protocols for congenital glottic and subglottic abnormalities.
Abstract:
Severe congenital glottic webs are often associated with subglottic stenosis. We treated two young children with combined anterior glottic web-subglottic stenosis with partial laryngofissure and anterior costal cartilage graft placement. We used a novel stent composed of silicone rubber, created from the external limb of a Hood (Pembroke, WA) tracheal T-tube. This stent served as both a subglottic stent and a glottic keel. These two children achieved decannulation with improved vocal quality.
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