Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of body temperature after aglepristone treatment in bitches.

Y Corrada1, P García, P E de la Sota

  • 1Clinical Department, Faculty of Veterinary Sciences, National University of La Plata, La Plata CC 296, Argentina.

Animal Reproduction Science
|May 25, 2005
PubMed
Summary

Aglepristone effectively terminated pregnancy in bitches, but the associated drop in body temperature is not a reliable indicator for monitoring this effect. Further research may explore its hypothalamic impact.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasonographic computer-assisted quantification of the intraluminal uterine content in female dogs.

Theriogenology·2025
Same author

Anti-Müllerian hormone in queens: Serum concentrations and total ovarian follicle population.

Theriogenology·2022
Same author

Non-invasive cardiovascular assessment of pregnancy in healthy female cats.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2020
Same author

Feline testicular ultrasonogram differentiates pre vs. postpubertal and normal vs. disrupted spermatogenesis.

Theriogenology·2020
Same author

Quantitative bidimentional and Doppler ultrasound assessment of the effect of a GnRH antagonist on canine prostatic hyperplasia.

Theriogenology·2020
Same author

Physical, histological, endocrinological and steroidogenical evaluation of male cats postnatally exposed to sexual steroids.

Theriogenology·2019

Area of Science:

  • Veterinary Pharmacology
  • Reproductive Biology

Background:

  • Anti-progestins are used for pregnancy termination in animals.
  • Aglepristone is an anti-progestin with potential abortifacient properties in canines.

Purpose of the Study:

  • To evaluate body temperature responses and abortion timing in pregnant bitches treated with aglepristone.
  • To determine if body temperature changes can be used to monitor pregnancy termination efficacy.

Main Methods:

  • Fifteen pregnant bitches received two doses of aglepristone (10 mg/kg SC) 24 hours apart.
  • Control group of seven pregnant bitches received no treatment.
  • Body temperature was monitored rectally for 6 days; serum progesterone was also assessed.

Main Results:

Related Experiment Videos

  • Pregnancy was terminated in 14 out of 15 treated bitches within 4.3 days.
  • Treated bitches showed a significant decrease in body temperature 24 hours post-treatment, which later normalized.
  • No significant changes in progesterone levels were observed; body temperature changes did not correlate with abortion timing.

Conclusions:

  • Aglepristone is effective for terminating pregnancy in bitches.
  • Body temperature monitoring is not a suitable clinical indicator for aglepristone's abortifacient effect.
  • The observed body temperature decrease may suggest hypothalamic effects of aglepristone.