Related Experiment Video
Updated: Aug 17, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Involvement of stress proteins in renal diseases
Mohammed S Razzaque1, Takashi Taguchi
1Department of Oral and Developmental Biology, arvard School of Dental Medicine, Boston, Mass., USA; Department of Pathology, Nagasaki University Graduate chool of Biomedical Sciences, Nagasaki, Japan.
Abstract:
Heat shock proteins (HSPs) are a distinctive class of proteins that have evolved to cope with stress to provide cellular defence against a wide range of cell injuries. HSPs play an important role in the assembly and folding of intracellular polypeptides, and help in restoring the biological activities of abnormal proteins. Cellular stress responses include a transient rearrangement of functional activities, in order to protect and maintain essential cellular functions, possibly by inducing HSPs. HSPs help in restoring protein homeostasis and assist in cellular recovery from stress, either by repairing damaged proteins through refolding or by degrading them. Recent studies have documented the important roles of stress proteins in renal cell survival and matrix remodeling in a number of acute and chronic renal diseases. This brief review summarizes some of the important aspects of HSPs and their relevance to various renal diseases.
More Related Videos
11:47Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
Published on: March 4, 2022
10:31Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Related Concept Videos
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Acute Kidney Injury II: Pathophysiology
Nephrotic Syndrome II : Assessment and Medical Management
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Nephrons
Regulation of the Unfolded Protein Response