Related Experiment Video
Updated: Aug 12, 2026
07:52
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
[Nephropathia caused by hantavirus puumala: a case report]
A López Montes1, J Pérez Martínez, I Lorenzo
1Unidad de Nefrología, Complejo Hospitalario Universitario de Albacete. auroralmontes@hotmail.com
Summary
Hantavirus infection can cause acute renal failure and thrombocytopenia. Early consideration of Puumala virus is crucial for patients presenting with these symptoms, especially in Europe.
Area of Science:
- Nephrology
- Infectious Diseases
- Virology
Background:
- Hantavirus infections are a significant cause of acute kidney injury.
- Puumala virus is a common Hantavirus strain in Europe.
- Early diagnosis is critical for managing Hantavirus-induced renal complications.
Observation:
- A German patient presented with fever, thrombocytopenia, and acute renal failure.
- Clinical signs included oliguria, mild proteinuria, and hematuria.
- Renal biopsy showed acute interstitial nephritis.
Findings:
- IgM antibodies against Hantavirus Puumala confirmed the infection.
- The patient's presentation mimicked other causes of acute kidney injury.
- Histopathology revealed interstitial nephritis without medullary hemorrhages.
Implications:
- Hantavirus infection should be suspected in patients with fever, thrombocytopenia, and acute renal failure.
- Geographic origin (North and Central Europe) is an important factor in diagnosis.
- Timely diagnosis and supportive care are essential for favorable outcomes in Hantavirus infections.
Related Concept Videos
01:27Acute Pyelonephritis I: Introduction
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...