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Detection of Post-translational Modifications on Native Intact Nucleosomes by ELISA
07:13

Detection of Post-translational Modifications on Native Intact Nucleosomes by ELISA

Published on: April 26, 2011

Stability of nucleosomal DNA fragments in serum

Stefan Holdenrieder1, Susanne Mueller, Petra Stieber

  • 1Institute of Clinical Chemistry, University of Munich, Munich, Germany. Stefan.Holdenrieder@.med.uni-muenchen.de

Clinical Chemistry
|May 26, 2005
PubMed
Abstract

No abstract available in PubMed .

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The Nucleosome02:33

The Nucleosome

DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...