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Modulite: a simple solution to a difficult problem
D A Lewis1, D Ganderton, B J Meakin
1Vectura Ltd., Chippenham, UK. david.lewis@vectura.com
Abstract:
The development of HFA-based pMDIs has proved difficult due to differences in the physico-chemical properties of CFC and HFA propellants. However, the development of solution formulations instead of suspensions has provided a way to formulate products whose cloud characteristics can be modulated in a controlled manner by permitting different formulation and device hardware variables. The new approach has proved successful in formulating several different drugs including steroids and has now been applied to developing a formoterol Modulite solution formulation characterized by good chemical stability, delivery performance, and clinical results.
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