Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis.
Walter S Speidl1, Markus Exner, Jasmin Amighi
1Department of Internal Medicine II, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
European Heart Journal
|May 27, 2005
Summary
Elevated levels of complement component C5a predict cardiovascular risk in patients with advanced atherosclerosis. Measuring C5a may enhance risk prediction beyond traditional inflammatory markers.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Biomarker Discovery
Background:
- Complement activation is implicated in atherosclerotic lesions.
- Complement component C5a has potent pro-inflammatory effects.
- The predictive value of plasma C5a for cardiovascular risk is unknown.
Purpose of the Study:
- To investigate if plasma C5a levels predict cardiovascular risk.
- To assess C5a's predictive value in patients with advanced atherosclerosis.
Main Methods:
- 173 patients with symptomatic peripheral artery disease were studied.
- Cardiovascular risk factors, C5a levels, and inflammatory markers were measured.
- Patients were followed for major adverse cardiovascular events (MACE).
Main Results:
- 65 MACE occurred in 49 patients (28%) over a median of 22 months.
- Higher C5a quartiles correlated with increased cumulative event rates (P=0.0077).
- Adjusted hazard ratios for MACE increased with C5a quartiles (P=0.038).
Conclusions:
- Elevated C5a is associated with increased cardiovascular risk in advanced atherosclerosis.
- C5a determination may improve cardiovascular risk prediction.
- C5a offers added predictive value beyond non-specific inflammatory markers.
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