Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Autoantigens act as tissue-specific chemoattractants.

Joost J Oppenheim¹, Hui Fang Dong, Paul Plotz

¹National Cancer Institute-Frederick, Center for Cancer Research, Laboratory of Molecular Immunoregulation, MD 21702-1201, USA. Oppenhei@ncifcrf.gov

Journal of Leukocyte Biology

|May 27, 2005

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial: Cancer Immunosurveillance.

Frontiers in immunology·2026

Same author

IAN, an intelligent system for omics data analysis and discovery.

Cell reports methods·2026

Same author

Communicating science.

Immunity·2026

Same author

Cells Engage Endogenous Malonate Synthesis to Drive Mitochondrial Metabolism.

bioRxiv : the preprint server for biology·2026

Same author

Quantitative imaging for assessing uveitis activity: A comprehensive review.

Survey of ophthalmology·2026

Same author

Immune checkpoints in a genetically engineered mouse model of spontaneous autoimmune uveitis.

Journal of immunology (Baltimore, Md. : 1950)·2026

Same journal

Correction to: IL-27 signaling negatively regulates FcɛRI-mediated mast cell activation and allergic response.

Journal of leukocyte biology·2026

Same journal

Autofluorescence enables detection and quantification of EETosis in human leukocyte cultures.

Journal of leukocyte biology·2026

Same journal

Cold Atmospheric Plasma as an Immunomodulator: Suppression of T-cell Hyperactivation and Graft-versus-Host Disease via Redox Regulation.

Journal of leukocyte biology·2026

Same journal

Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsis.

Journal of leukocyte biology·2026

Same journal

Eosinophil Essentials: Identification and Assessment of Activity.

Journal of leukocyte biology·2026

Same journal

Immune cell landscape reveals 5 immune-related subtypes and molecular characteristics with prognostic and therapeutic implications in pan-cancer.

Journal of leukocyte biology·2026

See all related articles

Self-antigens, like those in autoimmune diseases, attract immune cells (leukocytes) by interacting with specific receptors. This chemoattraction may primarily aid tissue repair, with autoimmunity arising from immune dysregulation.

Area of Science:

Immunology
Autoimmunity
Cellular Biology

Background:

Self-antigens are implicated in autoimmune diseases and solid tumors.
Many autoantigens induce leukocyte migration via Gi-protein-coupled receptors (GiPCR) on immature dendritic cells (iDC).

Purpose of the Study:

To investigate the chemoattractant properties of self-antigens linked to autoimmune diseases.
To explore the role of self-antigen chemoattraction in immune responses and tissue repair.

Main Methods:

Assessed chemoattraction of various self-antigens for leukocytes expressing specific chemokine receptors (CCR5, CCR3, CXCR5, CXCR3).
Evaluated the dose-dependent effects of autoantigens on dendritic cell (DC) migration and maturation.

Main Results:

Related Experiment Videos

Specific myositis-associated autoantigens (histidyl-tRNA synthetase, asparaginyl-tRNA synthetase) attracted CCR5/CCR3-expressing leukocytes.
Autoantigens associated with multiple sclerosis, type I diabetes, and uveitis were chemotactic for iDC via GiPCR.
High autoantigen concentrations (1000-fold higher) were required to induce DC maturation, suggesting a primary role in migration.

Conclusions:

Tissue-specific self-antigens act as chemoattractants, potentially facilitating tissue repair by alerting the immune system to damage.
Autoimmune responses may develop secondary to impaired immunoregulatory function, rather than being the primary role of autoantigens.